Product Overview

MOTS‑c is a mitochondria‑derived peptide (MDP) encoded by the mitochondrial genome, consisting of 16 amino acids. Unlike traditional mitochondrial proteins, this peptide can translocate from mitochondria to the cell nucleus, where it influences gene expression and cellular metabolism in response to metabolic stress.

MOTS‑c has emerged as a significant peptide in biochemical and physiology research due to its role in mitochondrial signaling, energy metabolism, and systemic metabolic regulation. It is supplied as a research‑grade peptide for use in experimental studies and scientific investigations.

Mechanism of Action (Research Context)

In laboratory studies, MOTS‑c is investigated for its ability to modulate cellular energy metabolism and metabolic signaling pathways. One of the key pathways associated with MOTS‑c’s activity is the AMP‑activated protein kinase (AMPK) signaling pathway, which plays a major role in regulating glucose and lipid metabolism when cellular energy is low.

MOTS‑c has also been shown to influence nuclear gene expression during metabolic stress, suggesting it might act as a mitochondrial‑nuclear communicator that helps cells adapt to changes in metabolic conditions.

Key Features & Research Highlights

📌 Mitochondria‑Derived Peptide: Encoded in the mitochondrial genome and studied as a signaling peptide with systemic metabolic roles.
📌 Regulator of Metabolism: MOTS‑c is involved in glucose metabolism, energy homeostasis, and insulin sensitivity.
📌 Exercise‑Mimetic Properties: Research shows that exercise increases MOTS‑c levels, and the peptide may help mimic some benefits of exercise in experimental models.
📌 Influence on Insulin Resistance: MOTS‑c has been linked to improved insulin sensitivity and metabolic balance in animal studies.
📌 Cellular Stress Response: It can act as a metabolic stress regulator by binding transcription factors and influencing nuclear gene expression.

Research Applications

Researchers use MOTS‑c in scientific and experimental studies to explore:

🔹 Mitochondrial signaling and gene expression regulation during metabolic stress.
🔹 Energy metabolism and glucose utilization mechanisms in cells or animal models.
🔹 Insulin sensitivity and metabolic disease models such as obesity or insulin resistance.
🔹 Exercise physiology and muscle metabolism research.
🔹 Inflammation and oxidative stress modulation pathways.

Biological & Chemical Profile

• Peptide Type: Mitochondria‑derived peptide
• Amino Acid Length: 16 amino acids
• Classification: Metabolic regulator peptide
• Form: Lyophilized white powder suitable for research use only
• CAS Number: 1627580‑64‑6 (commonly referenced for research peptides)

Usage & Safety Notice

✅ This product is intended strictly for laboratory and research use only.
❗ It is not intended for human or veterinary use, clinical treatment, or ingestion.
⚠️ Follow standard laboratory safety, handling, and storage practices when working with this peptide.